Two sample MR report
SLC12A7_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | -0.0553972 | 0.1079193 | 0.6133509 |
| Weighted median | 22 | -0.0436698 | 0.0160394 | 0.0064759 |
| Inverse variance weighted | 22 | -0.0398007 | 0.0123915 | 0.0013185 |
| Simple mode | 22 | -0.0650374 | 0.0283246 | 0.0320600 |
| Weighted mode | 22 | -0.0637676 | 0.0295290 | 0.0425285 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.746024 | 20 | 0.9934191 |
| Inverse variance weighted | 7.767189 | 21 | 0.9960545 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0088381 | 0.0607501 | 0.8857862 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006512 | 0 | TRUE | 0.0151896 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
