Two sample MR report
SLC17A5_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.0387206 | 0.0601342 | 0.5341273 |
| Weighted median | 12 | -0.0223830 | 0.0116160 | 0.0539905 |
| Inverse variance weighted | 12 | -0.0189002 | 0.0088285 | 0.0322902 |
| Simple mode | 12 | -0.0218697 | 0.0171470 | 0.2284346 |
| Weighted mode | 12 | -0.0212169 | 0.0159371 | 0.2100274 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.923537 | 10 | 0.8216459 |
| Inverse variance weighted | 6.034568 | 11 | 0.8710478 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0147733 | 0.0443359 | 0.7458539 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001391 | 0 | TRUE | 0.2625778 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
