Two sample MR report
SLC25A13_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0060321 | 0.2542558 | 0.9848994 |
| Weighted median | 3 | 0.0339571 | 0.0168730 | 0.0441657 |
| Inverse variance weighted | 3 | 0.0344175 | 0.0144163 | 0.0169676 |
| Simple mode | 3 | 0.0335330 | 0.0196347 | 0.2297892 |
| Weighted mode | 3 | 0.0333778 | 0.0194448 | 0.2282002 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0046500 | 1 | 0.9456338 |
| Inverse variance weighted | 0.0300413 | 2 | 0.9850916 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0204053 | 0.1280564 | 0.8994026 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.24e-05 | 0 | TRUE | 0.4933522 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
