Two sample MR report
SLFN5_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.1471867 | 0.4488694 | 0.7982822 |
| Weighted median | 3 | 0.0458262 | 0.0190257 | 0.0160117 |
| Inverse variance weighted | 3 | 0.0466313 | 0.0149819 | 0.0018551 |
| Simple mode | 3 | 0.0446308 | 0.0215083 | 0.1736622 |
| Weighted mode | 3 | 0.0447461 | 0.0212856 | 0.1702824 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0143609 | 1 | 0.9046123 |
| Inverse variance weighted | 0.0646016 | 2 | 0.9682153 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0468272 | 0.2089157 | 0.8596255 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.12e-05 | 0 | TRUE | 0.6004049 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
