Two sample MR report
SMDT1_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -0.0297850 | 0.0935564 | 0.7561712 |
| Weighted median | 13 | 0.0244013 | 0.0155548 | 0.1167110 |
| Inverse variance weighted | 13 | 0.0278341 | 0.0123938 | 0.0247167 |
| Simple mode | 13 | 0.0165652 | 0.0259914 | 0.5358799 |
| Weighted mode | 13 | 0.0461155 | 0.0245252 | 0.0845495 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.688076 | 11 | 0.9942394 |
| Inverse variance weighted | 3.074154 | 12 | 0.9949975 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0257839 | 0.0414965 | 0.5470286 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004791 | 0 | TRUE | 0.0373806 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
