Two sample MR report
SMDT1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.1966219 | 0.1582313 | 0.2454068 |
| Weighted median | 11 | -0.0690255 | 0.0269561 | 0.0104471 |
| Inverse variance weighted | 11 | -0.0514305 | 0.0219239 | 0.0189831 |
| Simple mode | 11 | -0.0710025 | 0.0422044 | 0.1234128 |
| Weighted mode | 11 | -0.0699706 | 0.0416294 | 0.1237205 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.861891 | 9 | 0.9934680 |
| Inverse variance weighted | 2.720342 | 10 | 0.9872613 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0657347 | 0.0709475 | 0.3783484 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004211 | 0 | TRUE | 0.0508648 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
