Two sample MR report
SMIM6_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 21 | -0.0489085 | 0.0869141 | 0.5802038 |
| Weighted median | 21 | -0.0208111 | 0.0069822 | 0.0028769 |
| Inverse variance weighted | 21 | -0.0195302 | 0.0053904 | 0.0002910 |
| Simple mode | 21 | -0.0206713 | 0.0116304 | 0.0907217 |
| Weighted mode | 21 | -0.0201474 | 0.0109716 | 0.0812196 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.677790 | 19 | 0.9999958 |
| Inverse variance weighted | 2.792486 | 20 | 0.9999978 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.014725 | 0.0434791 | 0.738574 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003442 | 0 | TRUE | 0.0775596 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
