Two sample MR report
SMIM6_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | -0.1347270 | 0.1144450 | 0.2529276 |
| Weighted median | 22 | -0.0498509 | 0.0112678 | 0.0000097 |
| Inverse variance weighted | 22 | -0.0361170 | 0.0080330 | 0.0000069 |
| Simple mode | 22 | -0.0571315 | 0.0215166 | 0.0148052 |
| Weighted mode | 22 | -0.0571315 | 0.0154423 | 0.0013291 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 18.90286 | 20 | 0.5281482 |
| Inverse variance weighted | 19.64895 | 21 | 0.5435840 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0491617 | 0.0569155 | 0.397957 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003717 | 0 | TRUE | 0.0679273 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
