Two sample MR report
SPAG17_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | 0.0066690 | 0.0773756 | 0.9323852 |
| Weighted median | 18 | -0.0245682 | 0.0098226 | 0.0123775 |
| Inverse variance weighted | 18 | -0.0240743 | 0.0073541 | 0.0010618 |
| Simple mode | 18 | -0.0234924 | 0.0163372 | 0.1685960 |
| Weighted mode | 18 | -0.0106551 | 0.0175623 | 0.5520648 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.390300 | 16 | 0.9934462 |
| Inverse variance weighted | 5.549606 | 17 | 0.9957366 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0117818 | 0.0295185 | 0.6950729 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003913 | 0 | TRUE | 0.06012 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
