Two sample MR report
SPAG17_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | 0.0071178 | 0.1402553 | 0.9601540 |
| Weighted median | 18 | -0.0725412 | 0.0160935 | 0.0000066 |
| Inverse variance weighted | 18 | -0.0791791 | 0.0122804 | 0.0000000 |
| Simple mode | 18 | -0.0729671 | 0.0272267 | 0.0158220 |
| Weighted mode | 18 | -0.0718754 | 0.0255845 | 0.0120659 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.119146 | 16 | 0.9867566 |
| Inverse variance weighted | 6.500645 | 17 | 0.9891403 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0324844 | 0.0525931 | 0.5454933 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000413 | 0 | TRUE | 0.0545975 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
