Two sample MR report
SPATA13_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0640319 | 0.1841871 | 0.7612841 |
| Weighted median | 4 | -0.0381862 | 0.0161511 | 0.0180636 |
| Inverse variance weighted | 4 | -0.0420919 | 0.0137994 | 0.0022863 |
| Simple mode | 4 | -0.0359812 | 0.0219067 | 0.1990324 |
| Weighted mode | 4 | -0.0359812 | 0.0217899 | 0.1972484 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0841956 | 2 | 0.9587760 |
| Inverse variance weighted | 0.4180459 | 3 | 0.9364899 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0565254 | 0.097829 | 0.6217845 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.51e-05 | 0 | TRUE | 0.5756153 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
