Two sample MR report
SPATA20_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | 0.0255119 | 0.0322944 | 0.4462360 |
| Weighted median | 13 | 0.0163863 | 0.0064548 | 0.0111293 |
| Inverse variance weighted | 13 | 0.0158085 | 0.0052210 | 0.0024629 |
| Simple mode | 13 | 0.0221041 | 0.0092579 | 0.0342861 |
| Weighted mode | 13 | 0.0175673 | 0.0081611 | 0.0524023 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.02789 | 11 | 0.2314539 |
| Inverse variance weighted | 14.14638 | 12 | 0.2914589 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0078101 | 0.0256231 | 0.7662016 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008532 | 0 | TRUE | 0.0054949 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
