Two sample MR report
SPATC1L_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0224432 | 0.0723413 | 0.8084888 |
| Weighted median | 3 | -0.0416752 | 0.0152850 | 0.0064003 |
| Inverse variance weighted | 3 | -0.0348639 | 0.0123003 | 0.0045912 |
| Simple mode | 3 | -0.0446727 | 0.0186572 | 0.1389699 |
| Weighted mode | 3 | -0.0446727 | 0.0205298 | 0.1615241 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7755381 | 1 | 0.3785092 |
| Inverse variance weighted | 1.4217656 | 2 | 0.4912104 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0424207 | 0.0527698 | 0.5689422 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.61e-05 | 0 | TRUE | 0.6309711 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
