Two sample MR report
STX11_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.2110156 | 0.1569455 | 0.4071165 |
| Weighted median | 3 | -0.0304186 | 0.0144884 | 0.0357719 |
| Inverse variance weighted | 3 | -0.0419328 | 0.0130621 | 0.0013261 |
| Simple mode | 3 | -0.0298262 | 0.0170099 | 0.2216152 |
| Weighted mode | 3 | -0.0297194 | 0.0161419 | 0.2069495 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5833465 | 1 | 0.4450036 |
| Inverse variance weighted | 3.1922326 | 2 | 0.2026821 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1915674 | 0.1186025 | 0.3529149 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.19e-05 | 0 | TRUE | 0.6652827 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
