Two sample MR report
TBC1D20_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0178031 | 0.2241414 | 0.9495405 |
| Weighted median | 3 | -0.0427780 | 0.0202519 | 0.0346612 |
| Inverse variance weighted | 3 | -0.0457114 | 0.0172416 | 0.0080201 |
| Simple mode | 3 | -0.0426918 | 0.0234194 | 0.2098888 |
| Weighted mode | 3 | -0.0426682 | 0.0238201 | 0.2151283 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0579850 | 1 | 0.8097096 |
| Inverse variance weighted | 0.0735805 | 2 | 0.9638783 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0251684 | 0.2015377 | 0.9209071 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.15e-05 | 0 | TRUE | 0.5951863 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
