Two sample MR report
TDRD3_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 19 | 0.0406162 | 0.0859674 | 0.6426063 |
| Weighted median | 19 | -0.0640639 | 0.0181954 | 0.0004301 |
| Inverse variance weighted | 19 | -0.0495513 | 0.0171104 | 0.0037799 |
| Simple mode | 19 | -0.0845537 | 0.0306494 | 0.0129290 |
| Weighted mode | 19 | -0.0740475 | 0.0305465 | 0.0261018 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 34.00780 | 17 | 0.0083767 |
| Inverse variance weighted | 36.29853 | 18 | 0.0064598 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0643454 | 0.0601306 | 0.2995354 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005319 | 0 | TRUE | 0.0291942 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
