Two sample MR report
THBS1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.1214481 | 0.3597848 | 0.7455930 |
| Weighted median | 9 | -0.0613700 | 0.0202422 | 0.0024312 |
| Inverse variance weighted | 9 | -0.0475189 | 0.0152968 | 0.0018934 |
| Simple mode | 9 | -0.0623263 | 0.0311531 | 0.0804357 |
| Weighted mode | 9 | -0.0623263 | 0.0302717 | 0.0734859 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.427656 | 7 | 0.6079237 |
| Inverse variance weighted | 5.648611 | 8 | 0.6865254 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0444335 | 0.0945276 | 0.6526056 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000133 | 0 | TRUE | 0.2753302 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
