Two sample MR report
TIMM10_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0561432 | 0.1203500 | 0.6726452 |
| Weighted median | 5 | 0.0434722 | 0.0289886 | 0.1337092 |
| Inverse variance weighted | 5 | 0.0546598 | 0.0245547 | 0.0260112 |
| Simple mode | 5 | 0.0416703 | 0.0380565 | 0.3350412 |
| Weighted mode | 5 | 0.0403071 | 0.0378625 | 0.3470679 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4443496 | 3 | 0.9309359 |
| Inverse variance weighted | 1.3288051 | 4 | 0.8564697 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0779442 | 0.0828792 | 0.4163639 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001667 | 0 | TRUE | 0.2198917 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
