Two sample MR report
TMEM176A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.1140270 | 0.2873452 | 0.7018692 |
| Weighted median | 10 | -0.0254310 | 0.0211898 | 0.2300791 |
| Inverse variance weighted | 10 | -0.0413867 | 0.0170630 | 0.0152864 |
| Simple mode | 10 | -0.0136436 | 0.0356133 | 0.7105354 |
| Weighted mode | 10 | -0.0146047 | 0.0346321 | 0.6831314 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.381444 | 8 | 0.8211737 |
| Inverse variance weighted | 4.675010 | 9 | 0.8616688 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0952087 | 0.1757213 | 0.6027042 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003401 | 0 | TRUE | 0.0796415 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
