Two sample MR report
TMEM176B_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.0736244 | 0.1466435 | 0.6264920 |
| Weighted median | 12 | -0.0362477 | 0.0188165 | 0.0540565 |
| Inverse variance weighted | 12 | -0.0473945 | 0.0151610 | 0.0017716 |
| Simple mode | 12 | -0.0248030 | 0.0328979 | 0.4667183 |
| Weighted mode | 12 | -0.0242996 | 0.0310312 | 0.4501167 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.325369 | 10 | 0.8684107 |
| Inverse variance weighted | 5.357709 | 11 | 0.9126137 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0163634 | 0.0909923 | 0.8608758 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004391 | 0 | TRUE | 0.0464164 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
