Two sample MR report
TMEM220_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.2293665 | 0.7324092 | 0.7837949 |
| Weighted median | 4 | 0.0637358 | 0.0192995 | 0.0009584 |
| Inverse variance weighted | 4 | 0.0595355 | 0.0163055 | 0.0002610 |
| Simple mode | 4 | 0.0644931 | 0.0266415 | 0.0941033 |
| Weighted mode | 4 | 0.0644931 | 0.0255432 | 0.0858100 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5470510 | 2 | 0.7606930 |
| Inverse variance weighted | 0.6008459 | 3 | 0.8962387 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0893582 | 0.3852688 | 0.8381576 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001143 | 0 | TRUE | 0.3134594 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
