Two sample MR report
TMEM220_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.1046219 | 0.5982020 | 0.8723005 |
| Weighted median | 5 | 0.1481473 | 0.0419747 | 0.0004164 |
| Inverse variance weighted | 5 | 0.1451072 | 0.0333307 | 0.0000134 |
| Simple mode | 5 | 0.1588494 | 0.0489551 | 0.0315305 |
| Weighted mode | 5 | 0.1587105 | 0.0534286 | 0.0411233 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0251973 | 3 | 0.9989442 |
| Inverse variance weighted | 0.2000180 | 4 | 0.9953203 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1057091 | 0.2528227 | 0.7039882 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.66e-05 | 0 | TRUE | 0.3545436 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
