Two sample MR report
TNFSF10_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0116652 | 0.0553435 | 0.8465655 |
| Weighted median | 5 | -0.0505093 | 0.0108759 | 0.0000034 |
| Inverse variance weighted | 5 | -0.0498043 | 0.0081646 | 0.0000000 |
| Simple mode | 5 | -0.0532965 | 0.0140709 | 0.0193071 |
| Weighted mode | 5 | -0.0521659 | 0.0135150 | 0.0181494 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0558562 | 3 | 0.9965473 |
| Inverse variance weighted | 0.5413277 | 4 | 0.9693550 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0300233 | 0.04309 | 0.5360904 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001166 | 0 | TRUE | 0.3120219 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
