Two sample MR report
TOB1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.1390818 | 0.1941676 | 0.5007237 |
| Weighted median | 8 | 0.0316038 | 0.0131415 | 0.0161776 |
| Inverse variance weighted | 8 | 0.0341178 | 0.0104551 | 0.0011013 |
| Simple mode | 8 | 0.0325195 | 0.0182947 | 0.1187215 |
| Weighted mode | 8 | 0.0314728 | 0.0183098 | 0.1293232 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5752685 | 6 | 0.9967984 |
| Inverse variance weighted | 1.3732650 | 7 | 0.9863761 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0758017 | 0.0848551 | 0.4060946 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.82e-05 | 0 | TRUE | 0.4020373 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
