Two sample MR report
TOR1B_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0663074 | 0.1687576 | 0.7144226 |
| Weighted median | 6 | 0.0332628 | 0.0146136 | 0.0228364 |
| Inverse variance weighted | 6 | 0.0333249 | 0.0124060 | 0.0072274 |
| Simple mode | 6 | 0.0332464 | 0.0210350 | 0.1748265 |
| Weighted mode | 6 | 0.0333813 | 0.0187433 | 0.1350266 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0377064 | 4 | 0.9998245 |
| Inverse variance weighted | 0.0761120 | 5 | 0.9999173 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0147648 | 0.0753409 | 0.8541841 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.44e-05 | 0 | TRUE | 0.3564807 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
