Two sample MR report
TOX_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.9908030 | 3.8388688 | 0.8391992 |
| Weighted median | 3 | 0.0337342 | 0.0180100 | 0.0610570 |
| Inverse variance weighted | 3 | 0.0312798 | 0.0140362 | 0.0258463 |
| Simple mode | 3 | 0.0339693 | 0.0198411 | 0.2290156 |
| Weighted mode | 3 | 0.0339693 | 0.0191716 | 0.2184283 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0126416 | 1 | 0.9104787 |
| Inverse variance weighted | 0.0751171 | 2 | 0.9631380 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.4837133 | 1.935231 | 0.844071 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.98e-05 | 0 | TRUE | 0.6048553 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
