Two sample MR report
TSTD1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0903183 | 0.0528001 | 0.1380105 |
| Weighted median | 8 | -0.0053615 | 0.0123375 | 0.6638725 |
| Inverse variance weighted | 8 | -0.0205833 | 0.0095321 | 0.0308216 |
| Simple mode | 8 | -0.0034950 | 0.0220967 | 0.8787917 |
| Weighted mode | 8 | -0.0026700 | 0.0187740 | 0.8909147 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7377074 | 6 | 0.9936409 |
| Inverse variance weighted | 5.2980365 | 7 | 0.6236426 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0667542 | 0.0312594 | 0.0766258 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001416 | 0 | TRUE | 0.2596589 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
