Two sample MR report
TUFM_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 20 | 0.0519424 | 0.1041005 | 0.6238478 |
| Weighted median | 20 | 0.0480402 | 0.0095250 | 0.0000005 |
| Inverse variance weighted | 20 | 0.0349838 | 0.0068300 | 0.0000003 |
| Simple mode | 20 | 0.0514741 | 0.0161754 | 0.0049056 |
| Weighted mode | 20 | 0.0511465 | 0.0150605 | 0.0030313 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 19.37751 | 18 | 0.3689312 |
| Inverse variance weighted | 19.40621 | 19 | 0.4310700 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.006842 | 0.0419045 | 0.8721194 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004315 | 0 | TRUE | 0.0492263 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
