Two sample MR report
UBXN11_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.1578579 | 0.0713247 | 0.0912973 |
| Weighted median | 6 | -0.0679348 | 0.0167027 | 0.0000476 |
| Inverse variance weighted | 6 | -0.0456380 | 0.0212353 | 0.0316218 |
| Simple mode | 6 | -0.0748691 | 0.0211924 | 0.0166895 |
| Weighted mode | 6 | -0.0732286 | 0.0216546 | 0.0196384 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.239846 | 4 | 0.2635611 |
| Inverse variance weighted | 16.297025 | 5 | 0.0060453 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1144496 | 0.0393932 | 0.0438837 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.97e-05 | 0 | TRUE | 0.5097941 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
