Two sample MR report
UCHL3_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0567127 | 0.1607021 | 0.7419710 |
| Weighted median | 6 | -0.0348677 | 0.0173645 | 0.0446439 |
| Inverse variance weighted | 6 | -0.0393058 | 0.0138805 | 0.0046296 |
| Simple mode | 6 | -0.0342547 | 0.0228581 | 0.1942578 |
| Weighted mode | 6 | -0.0333949 | 0.0223869 | 0.1959780 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6482173 | 4 | 0.9575579 |
| Inverse variance weighted | 0.6600381 | 5 | 0.9850897 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.010303 | 0.0947637 | 0.9186575 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001101 | 0 | TRUE | 0.3199798 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
