Two sample MR report
UCP2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.4825290 | 0.3214911 | 0.1936773 |
| Weighted median | 7 | -0.0735456 | 0.0421945 | 0.0813312 |
| Inverse variance weighted | 7 | -0.0632310 | 0.0320277 | 0.0483521 |
| Simple mode | 7 | -0.1294785 | 0.0653542 | 0.0948686 |
| Weighted mode | 7 | -0.1294785 | 0.0690347 | 0.1098294 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.107037 | 5 | 0.8341449 |
| Inverse variance weighted | 5.017736 | 6 | 0.5415404 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2043145 | 0.1197569 | 0.1487072 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001814 | 0 | TRUE | 0.2010811 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
