Two sample MR report
WAC-AS1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0320893 | 0.1110701 | 0.8209495 |
| Weighted median | 3 | -0.0396511 | 0.0209961 | 0.0589595 |
| Inverse variance weighted | 3 | -0.0339496 | 0.0162265 | 0.0364173 |
| Simple mode | 3 | -0.0411675 | 0.0231114 | 0.2168212 |
| Weighted mode | 3 | -0.0412274 | 0.0234632 | 0.2209789 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0159217 | 1 | 0.8995886 |
| Inverse variance weighted | 0.3771441 | 2 | 0.8281408 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0304879 | 0.0507271 | 0.655482 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.29e-05 | 0 | TRUE | 0.6505833 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
