Two sample MR report
WASHC2A_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.2762433 | 0.1675675 | 0.1977996 |
| Weighted median | 5 | -0.0379597 | 0.0164015 | 0.0206458 |
| Inverse variance weighted | 5 | -0.0366943 | 0.0130994 | 0.0050908 |
| Simple mode | 5 | -0.0587197 | 0.0248169 | 0.0771463 |
| Weighted mode | 5 | -0.0126653 | 0.0226828 | 0.6063710 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.038319 | 3 | 0.7919809 |
| Inverse variance weighted | 3.094548 | 4 | 0.5421295 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1149971 | 0.0801957 | 0.2470489 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5e-05 | 0 | TRUE | 0.5044114 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
