Two sample MR report
WBSCR27_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.3711147 | 0.6015906 | 0.6481112 |
| Weighted median | 3 | 0.0841056 | 0.0307118 | 0.0061712 |
| Inverse variance weighted | 3 | 0.0755374 | 0.0246232 | 0.0021568 |
| Simple mode | 3 | 0.0851504 | 0.0340524 | 0.1295635 |
| Weighted mode | 3 | 0.0851504 | 0.0371407 | 0.1488982 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0851026 | 1 | 0.7704981 |
| Inverse variance weighted | 0.3269092 | 2 | 0.8492050 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2306296 | 0.4690086 | 0.7090542 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.5e-05 | 0 | TRUE | 0.6380078 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
