Two sample MR report
WDR91_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0605697 | 0.1115833 | 0.6833998 |
| Weighted median | 3 | 0.0335450 | 0.0140355 | 0.0168479 |
| Inverse variance weighted | 3 | 0.0298929 | 0.0117145 | 0.0107173 |
| Simple mode | 3 | 0.0347368 | 0.0165322 | 0.1704071 |
| Weighted mode | 3 | 0.0347016 | 0.0171140 | 0.1797895 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2907830 | 1 | 0.5897192 |
| Inverse variance weighted | 0.3672079 | 2 | 0.8322653 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0195491 | 0.0707145 | 0.8282945 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.01e-05 | 0 | TRUE | 0.3969027 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
