Two sample MR report
WDSUB1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.1280633 | 0.2384628 | 0.6862506 |
| Weighted median | 3 | 0.0357837 | 0.0157833 | 0.0233784 |
| Inverse variance weighted | 3 | 0.0407379 | 0.0122042 | 0.0008437 |
| Simple mode | 3 | 0.0342010 | 0.0176507 | 0.1922579 |
| Weighted mode | 3 | 0.0340990 | 0.0185390 | 0.2072420 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1910134 | 1 | 0.6620745 |
| Inverse variance weighted | 0.6934129 | 2 | 0.7070128 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0981795 | 0.1385149 | 0.6074548 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.93e-05 | 0 | TRUE | 0.6108974 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
