Two sample MR report
XRRA1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0739141 | 0.0404207 | 0.1172118 |
| Weighted median | 8 | -0.0269725 | 0.0095955 | 0.0049396 |
| Inverse variance weighted | 8 | -0.0198722 | 0.0087618 | 0.0233260 |
| Simple mode | 8 | -0.0304523 | 0.0134377 | 0.0578023 |
| Weighted mode | 8 | -0.0314882 | 0.0146288 | 0.0683635 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.33571 | 6 | 0.3866528 |
| Inverse variance weighted | 12.18727 | 7 | 0.0945661 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0662495 | 0.0281429 | 0.0567443 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003036 | 0 | TRUE | 0.0987446 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
