Two sample MR report
ZNF506_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0741243 | 0.1384797 | 0.6208354 |
| Weighted median | 6 | 0.0141122 | 0.0103948 | 0.1745837 |
| Inverse variance weighted | 6 | 0.0176656 | 0.0083721 | 0.0348525 |
| Simple mode | 6 | 0.0136357 | 0.0146147 | 0.3936413 |
| Weighted mode | 6 | 0.0131733 | 0.0130320 | 0.3584792 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4258505 | 4 | 0.9803063 |
| Inverse variance weighted | 0.8668197 | 5 | 0.9725771 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0721591 | 0.1086643 | 0.5429763 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.75e-05 | 0 | TRUE | 0.471187 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
