Two sample MR report
ZNF506_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0825040 | 0.1455973 | 0.6012296 |
| Weighted median | 6 | -0.0147745 | 0.0110654 | 0.1818118 |
| Inverse variance weighted | 6 | -0.0190578 | 0.0089283 | 0.0327995 |
| Simple mode | 6 | -0.0141932 | 0.0152570 | 0.3949282 |
| Weighted mode | 6 | -0.0138126 | 0.0136082 | 0.3566694 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7710458 | 4 | 0.9422871 |
| Inverse variance weighted | 1.2594622 | 5 | 0.9390472 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0795939 | 0.1138897 | 0.5231364 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.75e-05 | 0 | TRUE | 0.4714153 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
