Two sample MR report
ZNF506_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.1202147 | 0.3415548 | 0.7426258 |
| Weighted median | 6 | -0.0723566 | 0.0247514 | 0.0034630 |
| Inverse variance weighted | 6 | -0.0640841 | 0.0205656 | 0.0018327 |
| Simple mode | 6 | -0.0757275 | 0.0353328 | 0.0849660 |
| Weighted mode | 6 | -0.0759077 | 0.0329770 | 0.0696130 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6099090 | 4 | 0.9619562 |
| Inverse variance weighted | 0.6370145 | 5 | 0.9862459 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.044111 | 0.2679284 | 0.8772143 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.75e-05 | 0 | TRUE | 0.4723742 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
