Two sample MR report
ZSWIM7_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | 0.0277817 | 0.0478959 | 0.5683639 |
| Weighted median | 22 | -0.0122415 | 0.0059696 | 0.0403022 |
| Inverse variance weighted | 22 | -0.0113452 | 0.0049233 | 0.0212008 |
| Simple mode | 22 | -0.0146392 | 0.0101839 | 0.1653175 |
| Weighted mode | 22 | -0.0140180 | 0.0106494 | 0.2022549 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.432006 | 20 | 1.0000000 |
| Inverse variance weighted | 2.106481 | 21 | 0.9999999 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0201859 | 0.024579 | 0.421178 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004736 | 0 | TRUE | 0.0382857 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
