Two sample MR report
ZSWIM7_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.1821446 | 0.0972503 | 0.0806972 |
| Weighted median | 17 | -0.0334425 | 0.0158690 | 0.0350819 |
| Inverse variance weighted | 17 | -0.0336788 | 0.0114283 | 0.0032091 |
| Simple mode | 17 | -0.0640194 | 0.0277265 | 0.0346295 |
| Weighted mode | 17 | -0.0344095 | 0.0234801 | 0.1621667 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.174956 | 15 | 0.9526117 |
| Inverse variance weighted | 12.169026 | 16 | 0.7322647 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1160257 | 0.0519191 | 0.0410733 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004389 | 0 | TRUE | 0.0465794 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
