Two sample MR report
ZSWIM7_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.1502330 | 0.1323248 | 0.2784031 |
| Weighted median | 14 | -0.1257617 | 0.0229676 | 0.0000000 |
| Inverse variance weighted | 14 | -0.1188743 | 0.0165715 | 0.0000000 |
| Simple mode | 14 | -0.1457545 | 0.0341318 | 0.0009121 |
| Weighted mode | 14 | -0.1439372 | 0.0363735 | 0.0016391 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.9896823 | 12 | 0.9999866 |
| Inverse variance weighted | 5.1914634 | 13 | 0.9707328 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1381247 | 0.0673837 | 0.0628912 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003432 | 0 | TRUE | 0.0804945 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
