

# Two sample MR report

---

## hemoglobin concentration (HGB) against Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium || id:finn-b-O15_OEDEM_PROTUR_HYPERT

Date: **24 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   34| 0.6979027| 0.3230592| 0.0383451|
|Weighted median           |   34| 0.6598272| 0.2309766| 0.0042809|
|Inverse variance weighted |   34| 0.5226597| 0.1627734| 0.0013229|
|Simple mode               |   34| 0.3262198| 0.4937588| 0.5133995|
|Weighted mode             |   34| 0.7166816| 0.2244433| 0.0030883|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 41.15035|   32| 0.1288974|
|Inverse variance weighted | 41.66072|   33| 0.1433417|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0044958| 0.0071363| 0.533178|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           6e-06|              0|TRUE                     |    0.5083192|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/hemoglobin_concentration_HGB_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/hemoglobin_concentration_HGB_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/hemoglobin_concentration_HGB_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/hemoglobin_concentration_HGB_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk8-1.png)
