

# Two sample MR report

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## hematocrit (HCT) against Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium || id:finn-b-O15_OEDEM_PROTUR_HYPERT

Date: **24 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |  306| -0.0173146| 0.1315983| 0.8954101|
|Weighted median           |  306|  0.1152670| 0.0905728| 0.2031441|
|Inverse variance weighted |  306|  0.1245776| 0.0622562| 0.0453874|
|Simple mode               |  306|  0.1320792| 0.2283698| 0.5634500|
|Weighted mode             |  306|  0.0817726| 0.1371458| 0.5514534|

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### Heterogeneity tests


|method                    |        Q| Q_df| Q_pval|
|:-------------------------|--------:|----:|------:|
|MR Egger                  | 443.1405|  304|  3e-07|
|Inverse variance weighted | 445.3228|  305|  3e-07|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0035206| 0.0028774| 0.2220714|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.97e-05|          2e-07|TRUE                     |     0.089771|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/hematocrit_HCT_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/hematocrit_HCT_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/hematocrit_HCT_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/hematocrit_HCT_against_Oedema_proteinuria_and_hypertensive_disorders_in_pregnancy_childbirth_and_the_puerperium__idfinnbO15OEDEMPROTURHYPERTchunk8-1.png)
