Two sample MR report
hematocrit (HCT) against Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium || id:finn-b-O15_OEDEM_PROTUR_HYPERT
Date: 24 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 306 | -0.0173146 | 0.1315983 | 0.8954101 |
| Weighted median | 306 | 0.1152670 | 0.0905728 | 0.2031441 |
| Inverse variance weighted | 306 | 0.1245776 | 0.0622562 | 0.0453874 |
| Simple mode | 306 | 0.1320792 | 0.2283698 | 0.5634500 |
| Weighted mode | 306 | 0.0817726 | 0.1371458 | 0.5514534 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 443.1405 | 304 | 3e-07 |
| Inverse variance weighted | 445.3228 | 305 | 3e-07 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0035206 | 0.0028774 | 0.2220714 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.97e-05 | 2e-07 | TRUE | 0.089771 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
