

# Two sample MR report

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## Polycystic ovary syndrome against Endometrial cancer || id:ebi-a-GCST006464

Date: **22 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |    9|  0.137| 0.272| 0.630|
|Weighted median           |    9| -0.028| 0.068| 0.682|
|Inverse variance weighted |    9| -0.040| 0.049| 0.406|
|Simple mode               |    9| -0.023| 0.104| 0.827|
|Weighted mode             |    9| -0.030| 0.103| 0.779|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 7.37|    7|  0.391|
|Inverse variance weighted | 7.84|    8|  0.450|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.023| 0.035| 0.529|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.789|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Polycystic_ovary_syndrome_against_Endometrial_cancer__idebiaGCST006464chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Polycystic_ovary_syndrome_against_Endometrial_cancer__idebiaGCST006464chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Polycystic_ovary_syndrome_against_Endometrial_cancer__idebiaGCST006464chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Polycystic_ovary_syndrome_against_Endometrial_cancer__idebiaGCST006464chunk8-1.png)
