Two sample MR report
Type 2 diabetes || id:ebi-a-GCST006867 against Parkinson’s disease || id:ebi-a-GCST90018894
Date: 06 October, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 213 | 0.012 | 0.086 | 0.891 |
| Weighted median | 213 | -0.063 | 0.066 | 0.343 |
| Inverse variance weighted | 213 | -0.039 | 0.037 | 0.290 |
| Simple mode | 213 | -0.318 | 0.144 | 0.028 |
| Weighted mode | 213 | -0.025 | 0.070 | 0.719 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 235 | 211 | 0.124 |
| Inverse variance weighted | 235 | 212 | 0.129 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.003 | 0.005 | 0.516 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.001 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
