# Two sample MR report

## Phosphatidylcholine (O-18:1_20:4) levels against Type 2 diabetes || id:finn-b-E4_DM2

Date: 22 January, 2026

### Results from two sample MR:

method | nsnp | b | se | pval
--- | --- | --- | --- | ---
MR Egger | 4 | 0.310 | 0.147 | 0.170
Weighted median | 4 | 0.113 | 0.037 | 0.002
Inverse variance weighted | 4 | 0.039 | 0.097 | 0.686
Simple mode | 4 | 0.071 | 0.074 | 0.409
Weighted mode | 4 | 0.112 | 0.038 | 0.059

### Heterogeneity tests

method | Q | Q_df | Q_pval
--- | --- | --- | ---
MR Egger | 9.08 | 2 | 0.011
Inverse variance weighted | 28.42 | 3 | 0.000

### Test for directional horizontal pleiotropy

egger_intercept | se | pval
--- | --- | ---
-0.053 | 0.026 | 0.175

### Test that the exposure is upstream of the outcome

snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval
--- | --- | --- | ---
0.002 | 0 | TRUE | 0.001

Note - R^2 values are approximate

### Forest plot of single SNP MR

### Comparison of results using different MR methods

### Funnel plot

### Leave-one-out sensitivity analysis