

# Two sample MR report

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## Phosphatidylcholine (O-18:1_20:4) levels against Type 2 diabetes || id:finn-b-E4_DM2

Date: **22 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |    4| 0.310| 0.147| 0.170|
|Weighted median           |    4| 0.113| 0.037| 0.002|
|Inverse variance weighted |    4| 0.039| 0.097| 0.686|
|Simple mode               |    4| 0.071| 0.074| 0.409|
|Weighted mode             |    4| 0.112| 0.038| 0.059|

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### Heterogeneity tests


|method                    |     Q| Q_df| Q_pval|
|:-------------------------|-----:|----:|------:|
|MR Egger                  |  9.08|    2|  0.011|
|Inverse variance weighted | 28.42|    3|  0.000|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.053| 0.026| 0.175|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           0.002|              0|TRUE                     |        0.001|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_O181204_levels_against_Type_2_diabetes__idfinnbE4DM2chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_O181204_levels_against_Type_2_diabetes__idfinnbE4DM2chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_O181204_levels_against_Type_2_diabetes__idfinnbE4DM2chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_O181204_levels_against_Type_2_diabetes__idfinnbE4DM2chunk8-1.png)
