

# Two sample MR report

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## genus.Escherichia.Shigella.id.3504 against Lung cancer || id:ebi-a-GCST90018875

Date: **18 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0527174| 0.3820555| 0.8969208|
|Weighted median           |    6| -0.2280025| 0.1563382| 0.1447322|
|Inverse variance weighted |    6| -0.3092539| 0.1167316| 0.0080665|
|Simple mode               |    6| -0.0697589| 0.2411334| 0.7839668|
|Weighted mode             |    6| -0.1245727| 0.2199978| 0.5956963|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.730280|    4| 0.3161083|
|Inverse variance weighted | 5.325116|    5| 0.3775037|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0225588| 0.0318075| 0.5173349|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        2.02e-05|              0|TRUE                     |    0.6385885|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/genusEscherichiaShigellaid3504_against_Lung_cancer__idebiaGCST90018875chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/genusEscherichiaShigellaid3504_against_Lung_cancer__idebiaGCST90018875chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/genusEscherichiaShigellaid3504_against_Lung_cancer__idebiaGCST90018875chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/genusEscherichiaShigellaid3504_against_Lung_cancer__idebiaGCST90018875chunk8-1.png)
