# Two sample MR report

## Concentration of VLDL particles || id:ebi-a-GCST90093000 against Type 2 diabetes || id:finn-b-E4_DM2

Date: 22 January, 2026

### Results from two sample MR:

method | nsnp | b | se | pval
--- | --- | --- | --- | ---
MR Egger | 56 | -0.159 | 0.126 | 0.212
Weighted median | 56 | 0.028 | 0.058 | 0.630
Inverse variance weighted | 56 | 0.010 | 0.069 | 0.885
Simple mode | 56 | -0.061 | 0.146 | 0.679
Weighted mode | 56 | 0.042 | 0.064 | 0.513

### Heterogeneity tests

method | Q | Q_df | Q_pval
--- | --- | --- | ---
MR Egger | 263 | 54 | 0
Inverse variance weighted | 275 | 55 | 0

### Test for directional horizontal pleiotropy

egger_intercept | se | pval
--- | --- | ---
0.011 | 0.007 | 0.117

### Test that the exposure is upstream of the outcome

snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval
--- | --- | --- | ---
0 | 0 | TRUE | 0.006

Note - R^2 values are approximate

### Forest plot of single SNP MR

### Comparison of results using different MR methods

### Funnel plot

### Leave-one-out sensitivity analysis