# Two sample MR report

## genus.Escherichia.Shigella.id.3504 against Lung cancer || id:ebi-a-GCST90018875

Date: 18 January, 2026

### Results from two sample MR:

method | nsnp | b | se | pval
--- | --- | --- | --- | ---
MR Egger | 6 | -0.0527174 | 0.3820555 | 0.8969208
Weighted median | 6 | -0.2280025 | 0.1563382 | 0.1447322
Inverse variance weighted | 6 | -0.3092539 | 0.1167316 | 0.0080665
Simple mode | 6 | -0.0697589 | 0.2411334 | 0.7839668
Weighted mode | 6 | -0.1245727 | 0.2199978 | 0.5956963

### Heterogeneity tests

method | Q | Q_df | Q_pval
--- | --- | --- | ---
MR Egger | 4.730280 | 4 | 0.3161083
Inverse variance weighted | 5.325116 | 5 | 0.3775037

### Test for directional horizontal pleiotropy

egger_intercept | se | pval
--- | --- | ---
-0.0225588 | 0.0318075 | 0.5173349

### Test that the exposure is upstream of the outcome

snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval
--- | --- | --- | ---
2.02e-05 | 0 | TRUE | 0.6385885

Note - R^2 values are approximate

### Forest plot of single SNP MR

### Comparison of results using different MR methods

### Funnel plot

### Leave-one-out sensitivity analysis