Two sample MR report
COPD || id:finn-b-J10_COPD against Non-small cell lung cancer (all cancers excluded) || id:finn-b-C3_LUNG_NONSMALL_EXALLC
Date: 18 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 29 | 0.284 | 0.237 | 0.240 |
| Weighted median | 29 | 0.253 | 0.107 | 0.018 |
| Inverse variance weighted | 29 | 0.452 | 0.106 | 0.000 |
| Simple mode | 29 | 0.174 | 0.223 | 0.442 |
| Weighted mode | 29 | 0.174 | 0.197 | 0.386 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 66.0 | 27 | 0 |
| Inverse variance weighted | 67.5 | 28 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.029 | 0.036 | 0.433 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.801 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
