Two sample MR report
Concentration of VLDL particles || id:ebi-a-GCST90093000 against Type 2 diabetes || id:finn-b-E4_DM2
Date: 22 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 56 | -0.159 | 0.126 | 0.212 |
| Weighted median | 56 | 0.028 | 0.058 | 0.630 |
| Inverse variance weighted | 56 | 0.010 | 0.069 | 0.885 |
| Simple mode | 56 | -0.061 | 0.146 | 0.679 |
| Weighted mode | 56 | 0.042 | 0.064 | 0.513 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 263 | 54 | 0 |
| Inverse variance weighted | 275 | 55 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.011 | 0.007 | 0.117 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.006 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
